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Posted on September 3, 2007 by Juliet Cohen | Posted under Diseases
Gilbert's Syndrome - Causes, Symptoms and Treatment Methods
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Gilbert's syndrome is most often recognised in the second or third decade of life and is rarely diagnosed before puberty. Men are often affected more than women. It can also frequently coexist with the conditions associated with unconjugated hyperbilirubinemia, such as thalassemia and glucose-6-phosphate deficiency. Gilbert's is often diagnosed in the late teens and early twenties. The condition is inherited and is relatively common being estimated to affect about 1 person in 20. The source of this hyperbilirubinemia is reduced activity of the enzyme (glucuronyl transferase) which conjugates bilirubin and some other lipophilic molecules. In people with Gilbert's syndrome, the bilirubin level often goes up and down. At times, it may be within the normal range. People with Gilbert's syndrome have an inherited abnormality that causes reduced production of an enzyme involved in processing bilirubin. It is often first diagnosed in the late teens or early twenties. Causes of Gilbert's syndrome The common causes and risk factor's of Gilbert's syndrome include the following: Mutation in the UDP-glucuronosyltransferase gene. Fasting: This produces an increase in the plasma unconjugated bilirubin level. Stress, such as trauma and overexertion. Menstrual periods. Intercurrent illness, such as a viral infection. Symptoms of Gilbert's syndrome Some sign and symptoms related to Gilbert's syndrome are as follows: Gilbert's Syndrome is generally harmless and does not produce any symptoms, although some sufferers complain of excessive fatigue. Mild jaundice (yellowing of skin and whites of eyes). Loss of appetite. Pain in the abdomen (uncommon). Weakness. Treatment of Gilbert's syndrome Here is list of the methods for treating Gilbert's syndrome: Gilbert's syndrome seems to be a lifelong disorder, but it usually doesn't need medical treatment. Medication that helps the enzyme work better may be used to treat the jaundice if it becomes a problem. Phenobarbitone in small doses can sometimes help clear the jaundice. People with Gilbert's syndrome don't typically need long-term monitoring of their condition or repeat blood tests. If you're distressed by jaundice, the barbiturate medication phenobarbital may reduce bilirubin levels. About The Author: Juliet Cohen writes articles for diseases cure and health care information. |
Tags: GILBERT'S SYNDROME INFORMATION, GILBERT'S SYNDROME CAUSES, GILBERT'S SYNDROME SYMPTOMS, GILBERT'S SYNDROME TREATMENT TIPS, GILBERT'S SYNDROME PREVENTI
